FFI is also a rare long chromosome mutation disease. Currently known common PRNP diseases are Creutzfeldt-Jakob disease, Kuru disease syndrome, and FFI. Hence, it is very necessary to perform PRNP examination in clinical diagnosis of FFI of depression.įatal familial insomnia (FFI) is a kind of hereditary prion protein (PRNP) diseases. PRNP examination is of guiding significance for the diagnosis of the FFI of depression. He was no longer able to move around on his own, and there were serious mental disorders. Mobility dysfunction of the patient was further aggravated. There were no obvious effects in the treatment using medicines such as Risperidone, Olanzapine, Alprazolam, Clonazepam, and Deanxit. And the patient was finally diagnosed as FFI. Imaging and genetic test results: the cranial magnetic resonance imaging showed frontal temporal lobe atrophy the polysomnography results showed no effective sleep the 14-3-3 test result of cerebrospinal fluid was negative the prion protein (PRNP) test showed that the D178N gene locus had mutations. Diagnosis:Ĭlinical manifestations: he had obvious abnormal mental behavior, rapidly progressing dementia symptoms, stubborn insomnia, abnormal movements and laryngeal stridor after falling asleep at night. Patient concerns:Ī male, aged 57 years old, with mental disorders and progressive memory decline one year before admission. The study was mainly to report the clinical symptoms and imaging and genetic characteristics of a FFI case with depression, with relevant literature summarized. įatal familial insomnia (FFI) is a rare clinical case.
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This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The authors have no conflicts of interests to disclose.ĭata sharing not applicable to this article as no datasets were generated or analyzed during the current study. This study was supported by the Science and technology project of Foshan Science and Technology Bureau (2020001005608, 1920001001018) and High-Level Hospital Development Program for Foshan “Climbing” Project (DF-04-02-002). A fatal familial insomnia patient newly diagnosed as having depression: A case report.
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How to cite this article: Yukang T, Jiaquan L, Xiaoling L, Yiliang L, Guohong X, Caixia X, Guojun X. ∗Correspondence: Liang Jiaquan, Department of Psychiatry, The Third People's Hospital of Foshan, Guangdong, People's Republic of China (e-mail: ).Ībbreviations: FFI = fatal familial insomnia, PCR = polymerase chain reaction, PRNP = prion protein. All my symptoms align and i can’t actually think at all I have no concentration and I barely can focus on what my parents are telling me.Department of Psychiatry, The Third People's Hospital of Foshan, Guangdong, People's Republic of China. I understand if I’m gonna get comments that I don’t have FFI but I just can’t bring it to myself to think that it could be something else. Please please I’m not trying to get hate for this post I’m just really really scared right now and I don’t have any idea what to do. My only assumption is that I have FFI, nothing at this point can explain my symptoms other then it. I also did try medications like Advil PMs and a few others but they did absolutely nothing in fact I think it’s worst now. I could say as of now I had probably went three days with out any sleep.
I’m so so tired but when I close my eyes nothing comes. I’m so fucking hazy right now as I’m writing this, I barely can coherently write this and my body feels painfully sluggish. This month has came up and it turns out that I had completely struggled this entire week to get a fragment of sleep. My insomnia however continues to get worst and worst. Starting this year I began to suddenly develop very severe insomnia which I never had issues with previously and I also developed issues with nocturnal sweating and mild balance issues, along with very bad heart rhythms. I didn’t understand why I was dealing with worsening progressive cognitive decline and my doctors told me they couldn’t figure out what’s wrong with me. Hello I’m F19, starting four years ago I began developing cognitive decline that led me to having to quit college just last year.
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